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Inhibitors with -phenyl-,-unsaturated carbonyl functionality Recently, it was reported that benzylidenehydantoin 18a , benzylidenepyrrolidinedione 18b , and benzylidenethiazolidine-2,4-dione 18c (Figure 8(a)) derivatives as potential tyrosinase inhibitors and using in vivo studies the compounds were proved to be an effective skin whitening agents 7780

Although differential sex-related gene or protein expression of CYP4A1 has not been previously reported, many CYPs including CYP7A1 and CYP1B1 have been reported to show sex-related gene expression patterns 81,82

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